Controversies on neuroprotection therapy in non-arteritic anterior ischaemic optic neuropathy

SS Hayreh - British journal of ophthalmology, 2020 - bjo.bmj.com
Objective There has long been a great interest in neuroprotection therapy for ischaemic
stroke and various types of optic neuropathies. In view of that, I reviewed the literature on the …

Steroids versus no steroids in nonarteritic anterior ischemic optic neuropathy: a randomized controlled trial

R Saxena, D Singh, M Sharma, M James, P Sharma… - Ophthalmology, 2018 - Elsevier
Purpose To examine the role of oral steroid therapy in the treatment of nondiabetic cases of
acute nonarteritic anterior ischemic optic neuropathy (NAAION). Design Randomized double …

Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia

WN Lin, K Kapupara, YT Wen, YH Chen, IH Pan… - Marine drugs, 2020 - mdpi.com
Astaxanthin, a xanthophyll belonging to the family of carotenoids, is a potent antioxidant.
However, much less is known about its protective effects on the oxidative stress of ischemic …

[HTML][HTML] Ischemic Optic Neuropathy: A Review of Current and Potential Future Pharmacotherapies

O Badla, BA Badla, A Almobayed, C Mendoza… - Pharmaceuticals, 2024 - mdpi.com
The treatment of arteritic anterior ischemic optic neuropathy (AAION), non-arteritic ischemic
optic neuropathy (NAAION), and posterior ischemic optic neuropathy (PION) is a topic of …

Neuroprotective effects of omega-3 polyunsaturated fatty acids in a rat model of anterior ischemic optic neuropathy

T Georgiou, YT Wen, CH Chang… - … & Visual Science, 2017 - iovs.arvojournals.org
Purpose: The purpose of this study was to investigate the therapeutic effect of omega-3
polyunsaturated fatty acid (ω-3 PUFA) administration in a rat model of anterior ischemic optic …

Choroidal and retinal anatomical responses following systemic corticosteroid therapy in Vogt–Koyanagi–Harada disease using swept-source optical coherence …

D Jaisankar, R Raman, HR Sharma… - Ocular Immunology …, 2019 - Taylor & Francis
Purpose: To assess structural changes in retina and choroid after systemic corticosteroid
therapy in Vogt–Koyanagi–Harada (VKH) disease using swept-source optical coherence …

Early applications of granulocyte colony-stimulating factor (G-CSF) can stabilize the blood–optic-nerve barrier and ameliorate inflammation in a rat model of anterior …

YT Wen, TL Huang, SP Huang… - Disease models & …, 2016 - journals.biologists.com
Granulocyte colony-stimulating factor (G-CSF) was reported to have a neuroprotective effect
in a rat model of anterior ischemic optic neuropathy (rAION model). However, the therapeutic …

Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury

K Kapupara, YT Wen, RK Tsai, SP Huang - Cell death & disease, 2017 - nature.com
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders.
Inflammation and oxidative stress are key players in ischemic injuries. Following retinal …

[HTML][HTML] Early methylprednisolone treatment can stabilize the blood-optic nerve barrier in a rat model of anterior ischemic optic neuropathy (rAION)

TL Huang, YT Wen, CH Chang… - … & Visual Science, 2017 - jov.arvojournals.org
Purpose: We investigated whether methylprednisolone (MP) treatment halting retinal
ganglion cell (RGC) death and having anti-inflammatory effect over a narrow therapeutic …

[HTML][HTML] Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip

YH Chen, YC Huang, CH Chen, YT Wen… - … & Visual Science, 2023 - tvst.arvojournals.org
Purpose: Photolabile paper-based chips were developed to isolate extracellular vesicles
(EVs) from small-volume samples (less than 30 µL), such as vitreous humor. Putative …