Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …

Infections caused by malaria parasites place an enormous burden on the world's poorest
communities. Breakthrough drugs with novel mechanisms of action are urgently needed. As …

Aminoacyl-tRNA synthetases (aaRSs) catalyze the esterification of tRNA with a cognate
amino acid and are essential enzymes in all three kingdoms of life. Due to their important …

Organophosphorus compounds play a vital role as nucleic acids, nucleotide coenzymes,
metabolic intermediates and are involved in many biochemical processes. They are part of …

Agrobacterium tumefaciens incites the formation of readily visible macroscopic structures
known as crown galls on plant tissues that it infects. Records from biologists as early as the …

Phosphorous-containing molecules are essential constituents of all living cells. While the
phosphate functional group is very common in small molecule natural products, nucleic …

Inhibition of tRNA aminoacylation has proven to be an effective antimicrobial strategy,
impeding an essential step of protein synthesis. Mupirocin, the well-known selective inhibitor …

For most antimicrobial compounds with intracellular targets, getting inside the cell is the
major obstacle limiting their activity. To pass this barrier some antibiotics mimic the …

The biocontrol of crown gall has been practised in Australia for 48 years. Control is so
efficient that it is difficult to find a galled stone fruit tree, when previously, crown gall had …

Aminoacyl-tRNA synthetases (aaRSs) are modular enzymes globally conserved in the three
kingdoms of life. All catalyze the same two-step reaction, ie, the attachment of a …