Inherited disorders of oxidative phosphorylation cause the clinically and genetically
heterogeneous diseases known as mitochondrial energy generation disorders, or …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

A considerable amount of knowledge has been produced during the last five years on the
bioenergetics of cancer cells, leading to a better understanding of the regulation of energy …

The study of mitochondrial diseases has revealed dramatic variability in the phenotypic
presentation of mitochondrial genetic defects. To attempt to understand this variability …

Calcium is believed to regulate mitochondrial oxidative phosphorylation, thereby
contributing to the maintenance of cellular energy homeostasis. Skeletal muscle, with an …

Several lines of evidence indicate that mitochondrial reactive oxygen species (ROS)
generation is the major source of oxidative stress in the cell. It has been shown that ROS …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple …

Cardiotoxic side-effects represent a serious complication of anticancer therapy with
anthracyclines, in particular with doxorubicin (DXR) being the leading drug of the group …

Evidence suggests that mitochondrial dysfunction is prominent in Alzheimer's disease (AD).
A failure of one or more of the mitochondrial electron transport chain enzymes or of F1F0 …

Kinetic models are critical to predict the dynamic behaviour of metabolic networks.
Mechanistic kinetic models for large networks remain uncommon due to the difficulty of fitting …