Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …

Pore-forming toxins (PFT) are water-soluble proteins that possess the remarkable ability to
self-assemble on the membrane of target cells, where they form pores causing cell damage …

Abstract Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer
properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer …

Actinoporins (APs) from sea anemones are~ 20 kDa pore forming toxins with a β-sandwich
structure flanked by two α-helices. The molecular mechanism of APs pore formation is …

Antimicrobial peptide magainin 2 forms pores in lipid membranes to induce leakage of
internal contents of cells, which is a main cause of its bactericidal activity. However, the …

The release of cytochrome c from mitochondria is a key signaling mechanism in apoptosis.
Although extramitochondrial proteins are thought to initiate this release, the exact …

Actinoporins are effective pore-forming toxins produced by sea anemones. These extremely
potent, basic 20kDa proteins readily form pores in membranes that contain sphingomyelin …

Membranes are mainly composed of a lipid bilayer and proteins, constituting a checkpoint
for the entry and passage of signals and other molecules. Their composition can be …

Two important questions on the molecular mechanism of the B cell CLL/lymphoma 2 (BCL2)
proteins involve the interaction network between pro-and antiapoptotic members and the …