An updated advance of autoantibodies in autoimmune diseases

ZX Xiao, JS Miller, SG Zheng - Autoimmunity reviews, 2021 - Elsevier
Autoantibodies are abnormal antibodies which are generated by pathogenic B cells when
targeting an individual's own tissue. Autoantibodies have been identified as a symbol of …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

S Wang, Y Wang - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2013 - Elsevier
Peptidylarginine deiminases are a family of enzymes that mediate post-translational
modifications of protein arginine residues by deimination or demethylimination to produce …

Cl-amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model

BM Biron, CS Chung, XM O'Brien, Y Chen… - Journal of innate …, 2017 - karger.com
Sepsis refers to the presence of a serious infection that correlates with systemic and
uncontrolled immune activation. Posttranslational histone modification plays an important …

A systematic review of serum biomarkers anti‐cyclic citrullinated peptide and rheumatoid factor as tests for rheumatoid arthritis

P Taylor, J Gartemann, J Hsieh… - Autoimmune …, 2011 - Wiley Online Library
This systematic review assesses the current status of anti‐cyclic citrullinated peptide (anti‐
CCP) and rheumatoid factor (RF) tests in the diagnosis and prognosis of rheumatoid arthritis …

Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease

S Hutfless, P Matos, MV Talor… - The Journal of …, 2011 - academic.oup.com
Abstract Introduction: Antibodies to thyroglobulin (Tg), thyroperoxidase (TPO), and TSH
receptor (TSH-R) are prevalent in autoimmune thyroid diseases. We aimed to assess …

Clinical tolerogenic dendritic cells: exploring therapeutic impact on human autoimmune disease

BE Phillips, Y Garciafigueroa, M Trucco… - Frontiers in …, 2017 - frontiersin.org
Tolerogenic dendritic cell (tDC)-based clinical trials for the treatment of autoimmune
diseases are now a reality. Clinical trials are currently exploring the effectiveness of tDC to …

Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis

J Lee, A Luria, C Rhodes, H Raghu… - …, 2017 - academic.oup.com
Objectives. The aim was to investigate the effects of nicotine on neutrophil extracellular traps
(NETs) formation in current and non-smokers and on a murine model of RA. Methods. We …

PAD4 deficiency leads to decreased organ dysfunction and improved survival in a dual insult model of hemorrhagic shock and sepsis

BM Biron, CS Chung, Y Chen, Z Wilson… - The Journal of …, 2018 - journals.aai.org
Indirect acute respiratory distress syndrome (iARDS) is caused by a nonpulmonary
inflammatory process resulting from insults such as nonpulmonary sepsis. Neutrophils are …

Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis

BJ Miriovsky, K Michaud, GM Thiele… - Annals of the …, 2010 - ard.bmj.com
Objective To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and
rheumatoid factor (RF) concentrations with future disease activity in men with rheumatoid …