The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Recent advances in our understanding of the molecular pathways that govern the
association of inflammation with organ fibrosis and cancer point to the epithelial to …

Unilateral ureteral obstruction (UUO) is an experimental rodent model that mimics renal
fibrosis associated with obstructive nephropathy in an accelerated manner. After UUO, the …

Interstitial fibrosis has a major role in the progression of renal diseases. Several animal
models are available for the study of renal fibrosis. The models of aminonucleoside-induced …

Transcription factor-κB (NF-κB) and renal disease. Nuclear factor-κB (NF-κB) comprises a
family of dimeric transcription factors that regulate the expression of numerous genes …

The overall production of nitric oxide (NO) is decreased in chronic kidney disease (CKD)
which contributes to cardiovascular events and further progression of kidney damage. There …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

We recently reported that the activation of nuclear factor-κB (NF-κB) promotes inflammation
in rats harboring both human renin and angiotensinogen genes (double-transgenic rats …

Protein overload stimulates RANTES production by proximal tubular cells depending on NF-
kB activation. Abnormal traffic of proteins through the glomerular capillary has an intrinsic …

Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free
radical in proximal tubular cells. Background Uremic toxins have been suggested to promote …