Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia
DC Javitt, R Freedman - American Journal of Psychiatry, 2015 - Am Psychiatric Assoc
Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible
pathophysiological mechanisms in schizophrenia, are now being recharacterized in the …
pathophysiological mechanisms in schizophrenia, are now being recharacterized in the …
Cognitive impairment associated with schizophrenia: from pathophysiology to treatment
DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?
JT Kantrowitz, DC Javitt - Brain research bulletin, 2010 - Elsevier
Schizophrenia is a severe mental disorder associated with a characteristic constellation of
symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively …
symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively …
When doors of perception close: bottom-up models of disrupted cognition in schizophrenia
DC Javitt - Annual review of clinical psychology, 2009 - annualreviews.org
Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of schizophrenia and a primary cause of long …
worldwide. Cognitive deficits are a key feature of schizophrenia and a primary cause of long …
Visual perception and its impairment in schizophrenia
PD Butler, SM Silverstein, SC Dakin - Biological psychiatry, 2008 - Elsevier
Much work in the cognitive neuroscience of schizophrenia has focused on attention,
memory, and executive functioning. To date, less work has focused on perceptual …
memory, and executive functioning. To date, less work has focused on perceptual …
Top-down predictions in the cognitive brain
The human brain is not a passive organ simply waiting to be activated by external stimuli.
Instead, we propose that the brain continuously employs memory of past experiences to …
Instead, we propose that the brain continuously employs memory of past experiences to …
Multimodal neuroimaging in schizophrenia: description and dissemination
CJ Aine, HJ Bockholt, JR Bustillo, JM Cañive… - Neuroinformatics, 2017 - Springer
In this paper we describe an open-access collection of multimodal neuroimaging data in
schizophrenia for release to the community. Data were acquired from approximately 100 …
schizophrenia for release to the community. Data were acquired from approximately 100 …
Neurophysiological biomarkers for drug development in schizophrenia
DC Javitt, KM Spencer, GK Thaker, G Winterer… - Nature Reviews Drug …, 2008 - nature.com
Schizophrenia represents a pervasive deficit in brain function, leading to hallucinations and
delusions, social withdrawal and a decline in cognitive performance. As the underlying …
delusions, social withdrawal and a decline in cognitive performance. As the underlying …
Early-stage visual processing deficits in schizophrenia
PD Butler, DC Javitt - Current opinion in psychiatry, 2005 - journals.lww.com
These findings highlight the importance of sensory processing deficits, in addition to higher
cognitive dysfunction, for understanding the pathophysiology of schizophrenia …
cognitive dysfunction, for understanding the pathophysiology of schizophrenia …
Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments
Visual processing deficits are an integral component of schizophrenia and are sensitive
predictors of schizophrenic decompensation in healthy adults. The primate visual system …
predictors of schizophrenic decompensation in healthy adults. The primate visual system …