Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …

Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …

The involvement of melatonin in mammalian brain pathophysiology has received growing
interest, but information about the anatomical distribution of its two G‐protein‐coupled …

Depression has become one of the most commonly prevalent neuropsychiatric disorders,
and the main characteristics of depression are sleep disorders and melatonin secretion …

Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …

Aims Anesthesia and surgery can cause delirium‐like symptoms postoperatively. Increasing
evidence suggests that gut microbiota is a physiological regulator of the brain. Herein, we …

Melatonin is synthesized by several tissues besides the pineal gland, and beyond its
regulatory effects in light-dark cycle, melatonin is a hormone with neuroprotective, anti …

The synthesis of melatonin (MLT) physiologically decreases during aging. Treatment with
MLT has shown anxiolytic, hypnotic, and analgesic effects, but little is known about possible …

Neuropathic pain is an important public health problem for which only a few treatments are
available. Preclinical studies show that melatonin (MLT), a neurohormone acting on MT1 …

Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery
of in vitro pharmacology assays to try to determine off-target interactions. During all phases …