Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …

In this Minireview, the importance and implementation of green chemistry practices in the
pharmaceutical industry are illustrated. With notable examples, some of the most important …

Chemical reactions for the formation of amide bonds are among the most commonly used
transformations in organic chemistry, yet they are often highly inefficient. A novel protocol for …

Solvents represent one of the major contributions to the environmental impact of fine‐
chemical synthesis. As a result, the use of environmentally friendly solvents in widely …

The generally accepted monoacyloxyboron mechanism of boron-catalysed direct amidation
is brought into question in this study, and new alternatives are proposed. We have carried …

Carbon‐heteroatom bond formation under transition‐metal free conditions provides a
powerful synthetic alternative for the efficient synthesis of valuable molecules. In particular …

Background: Among all the major post-translational modifications, amidation seems to be a
small change, where a peptide ends with an amide group (-NH 2), not a carboxyl group …

Methyltrimethoxysilane [MTM, CH3Si (OMe) 3] has been demonstrated to be an effective,
inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two …

We report the catalytic direct peptide bond formations via dehydrative condensation of β-
hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides …

Tetramethyl orthosilicate (TMOS) is shown to be an effective reagent for direct amidation of
aliphatic and aromatic carboxylic acids with amines and anilines. The amide products are …