Vascular mechanobiology: homeostasis, adaptation, and disease
JD Humphrey, MA Schwartz - Annual review of biomedical …, 2021 - annualreviews.org
Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …
[HTML][HTML] Constrained mixture models of soft tissue growth and remodeling–twenty years after
JD Humphrey - Journal of Elasticity, 2021 - Springer
Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …
each of which can possess individual natural configurations, material properties, and rates …
Spontaneous reversal of stenosis in tissue-engineered vascular grafts
We developed a tissue-engineered vascular graft (TEVG) for use in children and present
results of a US Food and Drug Administration (FDA)–approved clinical trial evaluating this …
results of a US Food and Drug Administration (FDA)–approved clinical trial evaluating this …
A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms
P Di Achille, G Tellides… - Proceedings of the …, 2014 - royalsocietypublishing.org
Intraluminal thrombus (ILT) is present in over 75% of all abdominal aortic aneurysms (AAAs)
and probably contributes to the complex biomechanics and pathobiology of these lesions. A …
and probably contributes to the complex biomechanics and pathobiology of these lesions. A …
Growth and remodeling of load-bearing biological soft tissues
CJ Cyron, JD Humphrey - Meccanica, 2017 - Springer
The past two decades reveal a growing role of continuum biomechanics in understanding
homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly …
homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly …
A homogenized constrained mixture (and mechanical analog) model for growth and remodeling of soft tissue
Most mathematical models of the growth and remodeling of load-bearing soft tissues are
based on one of two major approaches: a kinematic theory that specifies an evolution …
based on one of two major approaches: a kinematic theory that specifies an evolution …
Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension
MR Bersi, R Khosravi, AJ Wujciak… - Journal of The …, 2017 - royalsocietypublishing.org
The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …
Biomechanical investigation of disturbed hemodynamics-induced tissue degeneration in abdominal aortic aneurysms using computational and experimental …
Abdominal aortic aneurysm (AAA) is the dilatation of the aorta beyond 50% of the normal
vessel diameter. It is reported that 4–8% of men and 0.5–1% of women above 50 years of …
vessel diameter. It is reported that 4–8% of men and 0.5–1% of women above 50 years of …
Homogenized constrained mixture models for anisotropic volumetric growth and remodeling
Constrained mixture models for soft tissue growth and remodeling have attracted increasing
attention over the last decade. They can capture the effects of the simultaneous presence of …
attention over the last decade. They can capture the effects of the simultaneous presence of …
Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms
Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta that can lead to life-
threatening dissection or rupture. In vivo assessments of TAA progression are largely limited …
threatening dissection or rupture. In vivo assessments of TAA progression are largely limited …