Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Hypericum L. genus plants are distributed worldwide, with numerous species identified
throughout all continents, except Antarctica. These plant species are currently used in …

Hypericum is one out of the nine genera belonging to the botanical family Clusiaceae Lindl
(syn. Hypericaceae Juss.; APG III, 2009). The genus contains 484 species spread …

We report the first total synthesis of hypersampsone M, an archetypal member of the
homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs). Commencing …

Microbial infections are by no means a health problem from a past era due to the increasing
antimicrobial resistance of infectious strains. Medicine is in constant need of new drugs and …

Three novel 12, 13-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol (PPAP)
derivatives, named hyperilongenols A–C (1–3), were isolated from the stems and leaves of …

Hyperforin is a major active constituent of Hypericum perforatum (St. John's wort). It has
amazing pharmacological activities, such as antidepressant properties, but it is labile and …

A phytochemical investigation of the aerial parts of Hypericum annulatum Moris led to the
isolation of five new prenylated acylphloroglucinol derivatives hyperannulatins AE (1–3, 5 …

Hypericum perforatum L.(Hypericaceae), commonly known as St. John's Wort, is a widely
distributed herbaceous plant. It has been used for centuries in traditional medicine because …

Three new prenyloxy chromanone derivatives, aucherine AC (6, 7 and 9) as well as six
known prenylated phloroglucinols (1–5 and 8) were isolated from the aerial parts of …