Toll‐like receptors: general molecular and structural biology

P Behzadi, HA García-Perdomo… - Journal of Immunology …, 2021 - Wiley Online Library
Background/Aim. Toll‐like receptors (TLRs) are pivotal biomolecules in the immune system.
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …

The oyster immunity

L Wang, X Song, L Song - Developmental & Comparative Immunology, 2018 - Elsevier
Oysters, the common name for a number of different bivalve molluscs, are the worldwide
aquaculture species and also play vital roles in the function of ecosystem. As invertebrate …

Innate humoral immune defences in mammals and insects: The same, with differences?

G Sheehan, A Garvey, M Croke, K Kavanagh - Virulence, 2018 - Taylor & Francis
The insect immune response demonstrates many similarities to the innate immune response
of mammals and a wide range of insects is now employed to assess the virulence of …

Cytokines in atherosclerosis: pathogenic and regulatory pathways

A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

The evolution of vertebrate Toll-like receptors

JC Roach, G Glusman, L Rowen… - Proceedings of the …, 2005 - National Acad Sciences
The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from
many draft genomes enable comprehensive molecular phylogenetic analysis. Strong …

The insect cellular immune response

MR Strand - Insect science, 2008 - Wiley Online Library
The innate immune system of insects is divided into humoral defenses that include the
production of soluble effector molecules and cellular defenses like phagocytosis and …

Gene family innovation, conservation and loss on the animal stem lineage

DJ Richter, P Fozouni, MB Eisen, N King - elife, 2018 - elifesciences.org
Choanoflagellates, the closest living relatives of animals, can provide unique insights into
the changes in gene content that preceded the origin of animals. However, only two …

Evolutionary origins of toll-like receptor signaling

JJ Brennan, TD Gilmore - Molecular biology and evolution, 2018 - academic.oup.com
Toll-like receptors (TLRs) are transmembrane pattern recognition receptors that are best
known for their roles in innate immunity for the detection of and defense against microbial …

Use of defined TLR ligands as adjuvants within human vaccines

MS Duthie, HP Windish, CB Fox… - Immunological …, 2011 - Wiley Online Library
Our improved understanding of how innate immune responses can be initiated and how
they can shape adaptive B‐and T‐cell responses is having a significant impact on vaccine …

Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

RM Waterhouse, EV Kriventseva, S Meister, Z Xi… - science, 2007 - science.org
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public
health. The acquisition of the genome sequence of the yellow fever and Dengue vector …