Leishmaniasis is one of the six major tropical diseases targeted by the World Health
Organization. It is a life-threatening disease of medical, social and economic importance in …

Leishmaniasis covers a broad spectrum of diseases with distinct, and sometimes
overlapping, characteristics. The common thread in all forms of leishmaniasis is the infection …

Background The present study aimed to evaluate a hypothetical Leishmania amastigote-
specific protein (LiHyp1), previously identified by an immunoproteomic approach performed …

Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its
high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB …

The route of pathogen inoculation by needle has been shown to influence the outcome of
infection. Employing needle inoculation of the obligately intracellular parasite Leishmania …

Background The development of cost-effective prophylactic strategies to prevent
leishmaniasis has become a high-priority. The present study has used the phage display …

New therapeutics are urgently needed to treat visceral leishmaniasis (VL). Due to the fact
that drug discovery is a long and expensive process, the development of delivery systems to …

Parasitic protists belonging to the genus Leishmania synthesize the non-canonical
carbohydrate reserve, mannogen, which is composed of β-1, 2-mannan oligosaccharides …

Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania
infantum is one of main disease causative agents in the Americas. In a previous …

The present study aimed to investigate the in vitro antileishmanial activity of
strychnobiflavone flavonoid against Leishmania infantum, as well as its mechanism of …