Gene vectors are nucleic acids that carry genetic materials or gene editing devices into cells
to exert the sustained production of therapeutic proteins or to correct erroneous genes of the …

With the improvement of gene vectors, the rise of chimeric antigen receptor T cell
immunotherapy and breakthroughs in the genome editing technology, gene therapy had …

Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid
tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL) …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

Recent clinical trials of gene therapy have shown remarkable therapeutic benefits and an
excellent safety record. They provide evidence for the long-sought promise of gene therapy …

Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Adoptive cell therapy (ACT) is a kind of immunotherapy in which T cells are genetically
modified to express a chimeric antigen receptor (CAR) or T cell receptor (TCR), and ACT …

Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

Chimeric antigen receptor (CAR) T cell therapy has been successful in treating B cell
malignancies in clinical trials; however, fewer studies have evaluated CAR T cell therapy for …