Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

G-protein-coupled receptors (GPCRs) are activated by a diverse range of ligands, from large
proteins and proteases to small peptides, metabolites, neurotransmitters and ions. They are …

The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the
2.7 angstrom–resolution crystal structure of human CCR5 bound to the marketed HIV drug …

CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5
ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design …

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a
promising new strategy with potential for developing novel treatments for a variety of central …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The human immunodeficiency virus interacts with the cluster of differentiation 4 receptors
and one of the two chemokine receptors (CCR5 and CXCR4) to gain entry in human cells …

The control of cell migration by chemokines involves interactions with two types of receptors:
seven transmembrane chemokine‐type G protein‐coupled receptors and cell surface or …

This review focuses on the construction and application of structural chemokine receptor
models for the elucidation of molecular determinants of chemokine receptor modulation and …

CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites
of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide …