Notch signaling can have either an oncogenic or tumor-suppressive function in cancer
depending on the cancer type and cellular context. While Notch can be oncogenic in early …

Cellular plasticity in adult multicellular organisms is a protective mechanism that allows
certain tissues to regenerate in response to injury. Considering that aging involves exposure …

Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic
capacity. SCLC has been classified into molecular subtypes based on differential …

Lineage plasticity is a hallmark of cancer progression that impacts therapy outcomes, yet the
mechanisms mediating this process remain unclear. Here, we introduce a versatile in vivo …

The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) is a
recognized resistance mechanism and a hindrance to therapies using epidermal growth …

Targeting liver cancer stem cells (LCSCs) is a promising strategy for hepatocellular
carcinoma (HCC) therapy. Target selection and corresponding inhibitor screening are of …

Small-cell lung cancer (SCLC) transformation accounts for 3–14% of resistance in EGFR-TKI
relapsed lung adenocarcinomas (LUADs), with unknown molecular mechanisms and …

Neuroendocrine transdifferentiation (NEtD), also commonly referred to as lineage plasticity,
emerges as an acquired resistance mechanism to molecular targeted therapies in multiple …

The concurrence of chronic obstructive pulmonary disease (COPD) and lung cancer has
been widely reported and extensively addressed by pulmonologists and oncologists …

There are two main classes of lung cancer: non–small-cell lung cancer, which is
predominantly the lung adenocarcinoma (LUAD) subtype that originates from alveolar type 2 …