[HTML][HTML] Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins
S Ninagawa, G George, K Mori - … et biophysica acta (BBA)-General subjects, 2021 - Elsevier
Background The quality of proteins destined for the secretory pathway is ensured by two
distinct mechanisms in the endoplasmic reticulum (ER): productive folding of newly …
distinct mechanisms in the endoplasmic reticulum (ER): productive folding of newly …
[HTML][HTML] Induced pluripotent stem cells for neural drug discovery
Highlights•Neural diseases and neuropsychiatric diseases are growing global
problems.•Effective therapies for neurological diseases are still unmet medical …
problems.•Effective therapies for neurological diseases are still unmet medical …
Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity
Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …
[HTML][HTML] N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1
K Yang, R Huang, H Fujihira, T Suzuki… - The Journal of …, 2018 - ncbi.nlm.nih.gov
Mutations in the NGLY1 (N-glycanase 1) gene, encoding an evolutionarily conserved
deglycosylation enzyme, are associated with a rare congenital disorder leading to global …
deglycosylation enzyme, are associated with a rare congenital disorder leading to global …
Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase
Y Yoshida, M Asahina, A Murakami… - Proceedings of the …, 2021 - National Acad Sciences
Mutations in the human peptide: N-glycanase gene (NGLY1), which encodes a cytosolic de–
N-glycosylating enzyme, cause a congenital autosomal recessive disorder. In rodents, the …
N-glycosylating enzyme, cause a congenital autosomal recessive disorder. In rodents, the …
N-Glycosylation
T Hirata, Y Kizuka - The role of glycosylation in health and disease, 2021 - Springer
N-glycosylation is a highly conserved glycan modification, and more than 7000 proteins are
N-glycosylated in humans. N-glycosylation has many biological functions such as protein …
N-glycosylated in humans. N-glycosylation has many biological functions such as protein …
NGLY1: a fascinating, multifunctional molecule
T Suzuki, H Fujihira - Biochimica et Biophysica Acta (BBA)-General …, 2024 - Elsevier
NGLY1, a cytoplasmic de-N-glycosylating enzyme is well conserved among eukaryotes.
This enzyme has attracted considerable attention after mutations on the NGLY1 gene were …
This enzyme has attracted considerable attention after mutations on the NGLY1 gene were …
A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency
DM Talsness, KG Owings, E Coelho, G Mercenne… - elife, 2020 - elifesciences.org
N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function
mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by …
mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by …
NGLY1 deficiency, a congenital disorder of deglycosylation: from disease gene function to pathophysiology
N-Glycanase 1 (NGLY1) is a cytosolic enzyme involved in removing N-linked glycans of
misfolded N-glycoproteins and is considered to be a component of endoplasmic reticulum …
misfolded N-glycoproteins and is considered to be a component of endoplasmic reticulum …
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation
During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-
glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after …
glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after …