The activation of G protein-coupled receptors (GPCRs) is triggered by ligand binding to their
orthosteric sites, which induces ligand-specific conformational changes. Agonists and …

In the past, neuropeptide substance P (SP) was predominantly recognized as a
neuroinflammatory factor, while its potent healing activity was overlooked. This paper aims …

Many orphan G protein-coupled receptors (GPCRs) remain understudied because their
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …

G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of
heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear …

The CC motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has
emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has …

Cryogenic electron microscopy is widely used in structural biology, but its resolution is often
limited by the dynamics of the macromolecule. Here we developed a refinement protocol …

Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-
coupled receptors, is aberrantly overexpressed in several malignant tumors, including those …

Abstract Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the
hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist neurokinin B (NKB) …

G protein-coupled receptors (GPCRs) modulate every aspect of physiological functions
mainly through activating heterotrimeric G proteins. A majority of GPCRs promiscuously …

The endogenous cyclic tetradecapeptide SST14 was reported to stimulate all five
somatostatin receptors (SSTR1–5) for hormone release, neurotransmission, cell growth …