Preclinical antigen discovery, vaccine formulation, and efficacy studies in animal models
have progressed significantly in recent years. There is now a need to move promising …

While the incidence of many diseases has declined in developed countries, regions of the
world with low income and poor infrastructure continue to suffer a high burden of …

Streptococcus pyogenes causes at least 750 million infections and more than 500,000
deaths each year. No vaccine is currently available for S. pyogenes and the use of human …

Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic
fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes …

Background Streptococcus pyogenes is a leading cause of infection-related morbidity and
mortality. A reinvigorated vaccine development effort calls for new clinically relevant human …

Leishmaniasis is widely regarded as a vaccine-preventable disease, but the costs required
to reach pivotal Phase 3 studies and uncertainty about which candidate vaccines should be …

The genus Streptococcus comprises important pathogens, many of them are part of the
human or animal microbiota. Advances in molecular genetics, taxonomic approaches and …

Nearly a century after rheumatic fever (RF) and rheumatic heart disease (RHD) was
eradicated from the developed world, the disease remains endemic in many low-and middle …

Diabetes mellitus (DM) and its complications have become an important global public health
issue, affecting human health and negatively impacting life and lifespan. Pyroptosis is a …

Recent global advocacy efforts have highlighted the importance of development of a vaccine
against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that …