Recent developments in cardiac simulation have rendered the heart the most highly
integrated example of a virtual organ. We are on the brink of a revolution in cardiac …

The ventricular myocardium is known to exhibit a complex spatial organization, with fiber
orientation varying as a function of transmural location. It is now well established that …

To relate the subcellular molecular events to organ level physiology in heart, we have
developed a three-dimensional finite-element-based simulation program incorporating the …

One of the most recent trends in cardiac electrophysiology is the development of integrative
anatomically accurate models of the heart, which include description of cardiac activity from …

The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

Recent advances in biotechnology and the availability of ever more powerful computers
have led to the formulation of increasingly complex models at all levels of biology. One of the …

The physiome is the quantitative description of the functioning organism in normal and
pathophysiological states. The human physiome can be regarded as the virtual human. It is …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …

The development of cardiac ventricular cell models since 1960 is reviewed with the focus on
the interaction between simulation and experimental work. At each stage, the reasons for …

The purpose of this article is to give an overview of the forward problem of cardiac
electrophysiology. The relevant models are derived and the mathematical problem …