Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-
characterized pathological stages of initiation and progression. However, high-resolution …

CD4+ T cells that recognize tumor antigens are required for immune checkpoint inhibitor
efficacy in murine models, but their contributions in human cancer are unclear. We used …

Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts,
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …

Liver metastases are associated with poor response to current pharmacological treatments,
including immunotherapy. We describe a lentiviral vector (LV) platform to selectively …

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …

Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …

Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …