Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

The main problem of therapeutic efficiency lies in the crossing of cellular membranes.
Therefore, significant effort is being made to develop agents which can cross these barriers …

In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …

Protein transduction domains (PTD), such as the HIV TAT and the herpes simplex virus
VP22 proteins, are reported to translocate across the membranes of mammalian cells. The …

Gene therapy of cancer is a novel approach with the potential to selectively eradicate tumour
cells, whilst sparing normal tissue from damage. In particular, gene‐directed enzyme …

Polycationic macromolecules and cationic peptides acting as PTDs (protein transduction
domains) and CPPs (cell-penetrating peptides) represent important classes of agents used …

Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These
tumors are highly invasive, very aggressive, and often infiltrate critical neurological areas …

Hepatocellular carcinoma (HCC) is the sixth most common primary malignancy worldwide,
and the third most common cause of death among cancers worldwide. HCC occurs in …

Protein transduction with cell penetrating peptides over the past several years has been
shown to be an effective way of delivering proteins in vitro and now several reports have …

Over the past decade, several classes and/or prototypes of cell penetrating peptides (CPP)
have been identified and investigated in multiple aspects. CPP represent peptides, which …