RNA damage in biological conflicts and the diversity of responding RNA repair systems
AM Burroughs, L Aravind - Nucleic acids research, 2016 - academic.oup.com
RNA is targeted in biological conflicts by enzymatic toxins or effectors. A vast diversity of
systems which repair or 'heal'this damage has only recently become apparent. Here, we …
systems which repair or 'heal'this damage has only recently become apparent. Here, we …
The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation
S Tachiyama, KL Chan, X Liu… - Proceedings of the …, 2022 - National Acad Sciences
The flagellar motor stator is an ion channel nanomachine that assembles as a ring of the
MotA5MotB2 units at the flagellar base. The role of accessory proteins required for stator …
MotA5MotB2 units at the flagellar base. The role of accessory proteins required for stator …
Symmetry disruption commits vault particles to disassembly
Vaults are ubiquitous ribonucleoprotein particles involved in a diversity of cellular
processes, with promising applications as nanodevices for delivery of multiple cargos. The …
processes, with promising applications as nanodevices for delivery of multiple cargos. The …
Mechanical stability and reversible fracture of vault particles
Vaults are the largest ribonucleoprotein particles found in eukaryotic cells, with an unclear
cellular function and promising applications as vehicles for drug delivery. In this article, we …
cellular function and promising applications as vehicles for drug delivery. In this article, we …
Biophysical highlights from 54 years of macromolecular crystallography
JS Richardson, DC Richardson - Biophysical journal, 2014 - cell.com
Abstract The United Nations has declared 2014 the International Year of Crystallography,
and in commemoration, this review features a selection of 54 notable macromolecular …
and in commemoration, this review features a selection of 54 notable macromolecular …
Solution structures of engineered vault particles
Prior crystal structures of the vault have provided clues of its structural variability but are non-
conclusive due to crystal packing. Here, we obtained vaults by engineering at the N terminus …
conclusive due to crystal packing. Here, we obtained vaults by engineering at the N terminus …
Decrease in pH destabilizes individual vault nanocages by weakening the inter-protein lateral interaction
Vault particles are naturally occurring proteinaceous cages with promising application as
molecular containers. The use of vaults as functional transporters requires a profound …
molecular containers. The use of vaults as functional transporters requires a profound …
Direct visualization of vaults within intact cells by electron cryo-tomography
The vault complex is the largest cellular ribonucleoprotein complex ever characterized and
is present across diverse Eukarya. Despite significant information regarding the structure …
is present across diverse Eukarya. Despite significant information regarding the structure …
Structure, Dynamics and Functional Implications of the Eukaryotic Vault Complex
M González-Álamos, P Guerra, N Verdaguer - … Protein Complexes V …, 2024 - Springer
Vault ribonucleoprotein particles are naturally designed nanocages, widely found in the
eukaryotic kingdom. Vaults consist of 78 copies of the major vault protein (MVP) that are …
eukaryotic kingdom. Vaults consist of 78 copies of the major vault protein (MVP) that are …
Structure-based inference of eukaryotic complexity in Asgard archaea
Asgard archaea played a key role in the origin of the eukaryotic cell. While previous studies
found that Asgard genomes encode diverse eukaryotic signature proteins (ESPs) …
found that Asgard genomes encode diverse eukaryotic signature proteins (ESPs) …