This review briefly addresses the history of the discovery and elucidation of the three cloned
11β-hydroxysteroid dehydrogenase (11βHSD) enzymes in the human, 11βHSD1, 11βHSD2 …

The rapid and continual development of a number of radiopharmaceuticals targeting
different receptor, enzyme and small molecule systems has fostered Positron Emission …

BACKGROUND Investigations of stress dysregulation in posttraumatic stress disorder
(PTSD) have focused on peripheral cortisol, but none have examined cortisol in the human …

Post-traumatic stress disorder (PTSD) is characterized by the co-existence of a persistent
strong memory of the traumatic experience and amnesia for the peritraumatic context. Most …

Context The neural regulation of appetite and energy homeostasis significantly overlaps
with the neurobiology of stress. Frequent exposure to repeated acute stressors may cause …

Context Cortisol, a glucocorticoid steroid stress hormone, is primarily responsible for
stimulating gluconeogenesis in the liver and promoting adipocyte differentiation and …

Background Stress is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis,
initiating the release of glucocorticoid hormones, such as cortisol. Alcohol consumption can …

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an NADPH-
dependent reductase, responsible for the activation of cortisol by reducing cortisone …

Bariatric surgery, initially understood as restricting or bypassing the amount of food that
reaches the stomach to reduce food intake and/or increase malabsorption of food to promote …

Excess cortisol is associated with more severe cognitive decline, Alzheimer's disease, and
related dementia phenotypes. The intracellular enzyme 11β-HSD1 regenerates active …