Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

The cytosolic sulfotransferases (SULTs) are phase II conjugating enzymes that catalyze the
transfer of a sulfonate group from the universal sulfate donor 3′-phosphoadenosine-5 …

Previously, we demonstrated that Schisandrol B (SolB) protected against lithocholic acid
(LCA)-induced cholestatic liver injury (CLI) through pregnane X receptor (PXR). Additionally …

Drug resistance is one of the main causes of chemotherapy failure. Although several factors
are involved in cancer drug resistant, the exporter pumps overexpression that mediates the …

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Inhibition of APAP metabolic activation and promotion in APAP disposition are …

Cholangiopathies are poorly understood disorders with no effective therapy. The
extrahepatic biliary tree phenotype is less studied compared to the intrahepatic biliary injury …

Asarum is frequently applied in combination with other agents for prescriptions in practices
of Traditional Chinese Medicine. A number of studies have previously indicated that asarum …

Cholestasis is caused by the obstacle of bile formation or secretion and can develop into
severe liver diseases. We previously reported the ethanol extract of Schisandra …

Accumulation of toxic bile acids in liver could cause cholestasis and liver injury. The purpose
of the current study is to evaluate the hepatoprotective effect of yangonin, a product isolated …