Ultrasound proves to be an effective technique for intensifying a wide range of processes
involving solids and, as such, is often used to improve control over both solids formation and …

Interest in the continuous manufacturing in the pharmaceutical industry for the production of
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …

The rejection of process impurities from crystallizing products is an essential step for the
purification of pharmaceutical drugs and for the isolation of active pharmaceutical …

This review provides a summary of recent studies that addressed the question of whether
micro−/nanobubbles provide heterogeneous substrates to impact metastable zone width …

Crystallization is a widely used purification technique in the manufacture of active
pharmaceutical ingredients (APIs) and precursor molecules. However, when impurities and …

A P2X7 receptor antagonist (basic nature) with possible amino/imino tautomeric forms was
used as an active pharmaceutical ingredient (API). After the amorphous form was confirmed …

Selective crystallization of a pure product from complex mixtures is challenging due to the
variety of impurities which can potentially affect the crystallization process and hence …

Mathematical modeling of pharmaceutical manufacturing processes can provide insights
and understanding regarding the key factors impacting product quality. In this study, we …

Crystallization is an important unit operation in pharmaceutical drug substance
manufacturing for the isolation of organic products. Impurity control is a recurring critical …

Our company has developed a robust and scalable process to synthesize an amino alcohol
tosylate salt, a penultimate intermediate in the synthesis of nemtabrutinib. A key reaction in …