Gene function and cell surface protein association analysis based on single-cell multiomics data
Single-cell transcriptomics provides researchers with a powerful tool to resolve the
transcriptome heterogeneity of individual cells. However, this method falls short in revealing …
transcriptome heterogeneity of individual cells. However, this method falls short in revealing …
DNA methylation as a diagnostic, prognostic, and predictive biomarker in head and neck cancer
G Liouta, M Adamaki, A Tsintarakis… - International Journal of …, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a term collectively used to describe
all cancers that develop in the oral and nasal cavities, the paranasal sinuses, the salivary …
all cancers that develop in the oral and nasal cavities, the paranasal sinuses, the salivary …
CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors
YJ Liu, J Du, J Li, XP Tan, Q Zhang - Oncology Letters, 2023 - spandidos-publications.com
Collagen triple helix repeat containing 1 (CTHRC1) is a gene discovered in 2005; it is highly
conserved, and no homologous proteins have been disclosed thus far. A number of studies …
conserved, and no homologous proteins have been disclosed thus far. A number of studies …
CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15
Y Liu, X Chen, Y Xu, T Yang, H Wang, Z Wang… - Journal of Molecular …, 2024 - Springer
Tumor-associated macrophages (TAMs) represent a key factor in the tumor immune
microenvironment (TME), exerting significant influence over tumor migration, invasion …
microenvironment (TME), exerting significant influence over tumor migration, invasion …
CTHRC1 induces pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (myCAFs)
MK Kang, F Jiang, YJ Kim, K Ryu, A Masamune… - Cancers, 2023 - mdpi.com
Simple Summary CTHRC1 is a protein with pro-tumoral effects that is highly expressed in
tumors. We found that cancer stroma is the major source of CTHRC1 secretion in pancreatic …
tumors. We found that cancer stroma is the major source of CTHRC1 secretion in pancreatic …
[HTML][HTML] Unlocking the diagnostic, prognostic roles, and immune implications of BAX gene expression in pan-cancer analysis
MA Abdel-Maksoud, S Ullah, A Nadeem… - American Journal of …, 2024 - ncbi.nlm.nih.gov
Objectives: Cancer, a formidable disease, continues to challenge our understanding and
therapeutic approaches. This study delves into the pan-cancer analysis of BCL2 Associated …
therapeutic approaches. This study delves into the pan-cancer analysis of BCL2 Associated …
CTHRC1+ fibroblasts and SPP1+ macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma
E Li, HC Cheung, S Ma - Scientific Reports, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer that accounts for
over 90% of all pancreatic cancer cases. With a 5-year survival rate of only 13%, PDAC has …
over 90% of all pancreatic cancer cases. With a 5-year survival rate of only 13%, PDAC has …
[HTML][HTML] Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined in silico and in vitro approach
M Malik, M Maqbool, T Nisar, T Akhter, JA Ujan… - Oncology …, 2023 - ncbi.nlm.nih.gov
The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely
attributed to cisplatin resistance. Rather than focusing solely on individual proteins …
attributed to cisplatin resistance. Rather than focusing solely on individual proteins …
The role of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in cancer development and progression
Introduction Collagen triple helix repeat containing 1 (CTHRC1) is a protein that has been
implicated in pro-migratory pathways, arterial tissue-repair processes, and inhibition of …
implicated in pro-migratory pathways, arterial tissue-repair processes, and inhibition of …
CTHRC1 is associated with immune cell infiltration and functions as an adverse marker for prognosis in head and neck squamous cell carcinoma
R Zhong, M Yang, R Zhu, J Zhang… - Oncology …, 2023 - spandidos-publications.com
Collagen triple helix repeat containing 1 (CTHRC1) is a secreted glycoprotein that
decreases the deposition of collagen matrix and accelerates tumor metastasis. However, the …
decreases the deposition of collagen matrix and accelerates tumor metastasis. However, the …