Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic
and glutamatergic synapses resulting in global dysconnectivity within and between brain …

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

Schizophrenia is a severe mental illness characterized by alterations in processes that
regulate both synaptic plasticity and functional connectivity between brain regions …

Whole-brain mapping of drug effects are needed to understand the neural underpinnings of
drug-related behaviors. Amphetamine administration is associated with robust increases in …

While all reversible receptor-targeting radioligands for positron emission tomography (PET)
can be displaced by competition with an antagonist at the receptor, many radiotracers show …

Prefrontal cortex has been shown to regulate striatal dopaminergic function via
glutamatergic mechanisms in preclinical studies. Concurrent disruption of these systems is …

A series of bitopic ligands based on Fallypride with a flexible secondary binding fragment
(SBF) were prepared with the goal of preparing a D3R-selective compound. The effect of the …

Background Clinical and translational research has identified deficits in the dopaminergic
neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to …

Abstract Alpha-methyl-para-tyrosine (AMPT), a competitive inhibitor of tyrosine hydroxylase,
can be used to deplete endogenous dopamine in humans. We examined how AMPT …

The midbrain dopamine system contributes to important neural functions in the basal
ganglia, and is involved in aspects of pathological processes in schizophrenia. In preclinical …