[HTML][HTML] Multifunctional biomolecule nanostructures for cancer therapy

J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment

J Park, Y Choi, H Chang, W Um, JH Ryu, IC Kwon - Theranostics, 2019 - ncbi.nlm.nih.gov
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016 - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Y Wang, Y Jiang, D Wei, P Singh, Y Yu, T Lee… - Nature biomedical …, 2021 - nature.com
In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits
any survival benefits conferred by the drug. Here we show that the convection-enhanced …

[HTML][HTML] Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect

V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

Polysaccharide-based nanoparticles for theranostic nanomedicine

M Swierczewska, HS Han, K Kim, JH Park… - Advanced drug delivery …, 2016 - Elsevier
Polysaccharides are natural biological molecules that have numerous advantages for
theranostics, the integrated approach of therapeutics and diagnostics. Their derivable …

[HTML][HTML] ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

DG You, VG Deepagan, W Um, S Jeon, S Son… - Scientific reports, 2016 - nature.com
The non-invasive photodynamic therapy has been limited to treat superficial tumours,
primarily ascribed to poor tissue penetration of light as the energy source. Herein, we …

Current-status and applications of polysaccharides in drug delivery systems

P Prasher, M Sharma, M Mehta, S Satija… - Colloid and Interface …, 2021 - Elsevier
The polysaccharide-based advanced drug delivery system owing to their biocompatibility,
ability to encapsulate the drug molecules in their interspaces, and ability to achieve a …

[HTML][HTML] Recent progress and advances in stimuli-responsive polymers for cancer therapy

NV Rao, H Ko, J Lee, JH Park - Frontiers in bioengineering and …, 2018 - frontiersin.org
The conventional chemotherapeutic agents, used for cancer chemotherapy, have major
limitations including non-specificity, ubiquitous biodistribution, low concentration in tumor …

Natural polysaccharides based self-assembled nanoparticles for biomedical applications–A review

Y Fan, Y Liu, Y Wu, F Dai, M Yuan, F Wang… - International Journal of …, 2021 - Elsevier
In recent years, nanoparticles (NPs) derived from the self-assembly of natural
polysaccharides have shown great potential in the biomedical field. Here, we described …