Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

K Cwiklinski, S Donnelly, O Drysdale, H Jewhurst… - Advances in …, 2019 - Elsevier
Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human …

SN McNulty, JF Tort, G Rinaldi, K Fischer… - PLoS …, 2017 - journals.plos.org
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted
through the food chain, four of which are recognized as neglected tropical diseases (NTDs) …

The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for …

CN Davis, H Phillips, JJ Tomes, MT Swain… - PLoS neglected …, 2019 - journals.plos.org
Background Robust protocols for the isolation of extracellular vesicles (EVs) from the rest of
their excretory-secretory products are necessary for downstream studies and application …

Infection by the helminth parasite Fasciola hepatica requires rapid regulation of metabolic, virulence, and invasive factors to adjust to its mammalian host

K Cwiklinski, H Jewhurst, P McVeigh, T Barbour… - Molecular & Cellular …, 2018 - ASBMB
The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following
ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge …

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the …

K Cwiklinski, MW Robinson, S Donnelly, JP Dalton - BMC genomics, 2021 - Springer
Background The major pathogenesis associated with Fasciola hepatica infection results
from the extensive tissue damage caused by the tunnelling and feeding activity of immature …

Insights into Fasciola hepatica juveniles: crossing the fasciolosis rubicon

J González-Miguel, D Becerro-Recio… - Trends in …, 2021 - cell.com
Unraveling the molecular interactions governing the first contact between parasite and host
tissues is of paramount importance to the development of effective control strategies against …

Omics tools enabling vaccine discovery against fasciolosis

K Cwiklinski, JP Dalton - Trends in Parasitology, 2022 - cell.com
In the past decade significant advances in our understanding of liver fluke biology have
been made through in-depth interrogation and analysis of evolving Fasciola hepatica and …

Advances in Fasciola hepatica research using 'omics' technologies

K Cwiklinski, JP Dalton - International journal for parasitology, 2018 - Elsevier
The liver fluke Fasciola hepatica is an economically important pathogen of livestock
worldwide, as well as being an important neglected zoonosis. Parasite control is reliant on …

Towards the comprehension of fasciolosis (re-) emergence: an integrative overview

A Alba, AA Vazquez, S Hurtrez-Boussès - Parasitology, 2021 - cambridge.org
The increasing distribution and prevalence of fasciolosis in both human and livestock are
concerning. Here, we examine the various types of factors influencing fasciolosis …