Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome

RE Frye, S Rose, J Slattery… - Microbial ecology in …, 2015 - Taylor & Francis
Autism spectrum disorder (ASD) affects a significant number of individuals worldwide with
the prevalence continuing to grow. It is becoming clear that a large subgroup of individuals …

Sarcopenia and critical illness: a deadly combination in the elderly

JS Hanna - Journal of Parenteral and Enteral Nutrition, 2015 - Wiley Online Library
Sarcopenia is the age‐associated loss of lean skeletal muscle mass. It is the result of
multiple physiologic derangements, ultimately resulting in an insidious functional decline …

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate

K Lewis, F Lutgendorff, V Phan… - Inflammatory bowel …, 2010 - academic.oup.com
Background The gut microflora in some patients with Crohn's disease can be reduced in
numbers of butyrate-producing bacteria and this could result in metabolic stress in the …

The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease

SA Snoek, MI Verstege, GE Boeckxstaens… - Expert Review of …, 2010 - Taylor & Francis
The intestinal epithelia proliferate and differentiate along the crypt villus axis to constitute a
barrier cell layer separating some 1013 potentially harmful bacteria from a sterile mucosal …

The potential role for xanthine oxidase inhibition in major intra-abdominal surgery

A Mittal, ARJ Phillips, B Loveday, JA Windsor - World journal of surgery, 2008 - Springer
Background Xanthine oxidase (XO) is a cytosolic metalloflavoprotein that has been
implicated in the pathogenesis of a wide spectrum of diseases, and is thought to be the most …

Role of intestine in postsurgical complications: involvement of free radicals

S Thomas, KA Balasubramanian - Free Radical Biology and Medicine, 2004 - Elsevier
Surgery at any location in the body leads to surgical stress response and alterations in
normal body homeostasis. The intestine is extremely sensitive to surgical stress even at …

Metabolic Stress Evokes Decreases in Epithelial Barrier Function: Mechanistic Insights from in Vitro and in Vivo Model Systems

K Lewis, DM McKay - Annals of the New York Academy of …, 2009 - Wiley Online Library
The epithelial lining of the gastrointestinal tract is the major interface between the external
world (eg, the gut lumen) and the body, and as such the proper maintenance and regulation …

Is metabolic stress a common denominator in inflammatory bowel disease?

I Schoultz, JD Söderholm… - Inflammatory bowel …, 2011 - academic.oup.com
The enteric epithelium represents the major boundary between the outside world and the
body, and in the colon it is the interface between the host and a vast and diverse microbiota …

Surgical manipulation of the intestine and distant organ damage—protection by oral glutamine supplementation

S Thomas, R Prabhu, KA Balasubramanian - Surgery, 2005 - Elsevier
BACKGROUND: The intestine is increasingly recognized as a primary effector of distant
organ damage, such as the lung, after any abdominal surgery. Earlier studies have shown …

Amelioration of Intestinal Ischemia–Reperfusion Injury with Intraluminal Hyperoxygenated Solution: Studies on Structural and Functional Changes of Enterocyte …

C Gao, L Xu, W Chai, X Sun, H Zhang… - Journal of Surgical …, 2005 - Elsevier
BACKGROUND: The aim of this study was to investigate the effects of intraluminal
hyperoxygenated solution (HOS) on enterocyte mitochondrial structure and respiratory …