Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems—A critical review

M Böl, K Schrinner, S Tesche… - Engineering in life …, 2021 - Wiley Online Library
Filamentous microorganisms are main producers of organic acids, enzymes, and
pharmaceutical agents such as antibiotics and other active pharmaceutical ingredients. With …

Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms

AR Laible, A Dinius, M Schrader, R Krull… - Engineering in life …, 2022 - Wiley Online Library
Filamentous microorganisms are used as molecular factories in industrial biotechnology. In
2007, a new approach to improve productivity in submerged cultivation was introduced …

Enhancing Monascus Pellet Formation for Improved Secondary Metabolite Production

X Zhang, H Liu, M Zhang, W Chen, C Wang - Journal of Fungi, 2023 - mdpi.com
Filamentous fungi are well-known for their ability to form mycelial pellets during submerged
cultures, a characteristic that has been extensively studied and applied. However …

Transcriptomic Analysis of Morphology Regulatory Mechanisms of Microparticles to Paraisaria dubia in Submerged Fermentation

LL Tong, Y Wang, YH Du, L Yuan, MZ Liu… - Applied Biochemistry …, 2022 - Springer
Liquid submerged fermentation is an effective strategy to achieve large-scale production of
active ingredients by macrofungi, and controlling mycelium morphology is a key factor …

Morphological engineering of filamentous fungi: Research progress and perspectives

Z Lu, Z Chen, Y Liu, X Hua, C Gao… - Journal of Microbiology …, 2024 - pmc.ncbi.nlm.nih.gov
Filamentous fungi are important cell factories for the production of high-value enzymes and
chemicals for the food, chemical, and pharmaceutical industries. Under submerged …

The serine/threonine protein kinase MpSTE1 directly governs hyphal branching in Monascus spp.

Y Duan, X Chen, T Wang, M Li - Applied Microbiology and Biotechnology, 2024 - Springer
Monascus spp. are commercially important fungi due to their ability to produce beneficial
secondary metabolites such as the cholesterol-lowering agent lovastatin and natural food …

Regulation of citrinin biosynthesis in Monascus purpureus: Impacts on growth, morphology, and pigments production

X Zhang, W Chen, C Wang - Food Microbiology, 2025 - Elsevier
Fungal hyphae self-assemble a variety of cellular macrostates, ranging from suspended
mycelium to dense pellets, all inextricably linked to their productivity. In this study, using …

Novel approaches to improve lovastatin production in membrane gradostat bioreactor

SM Takloo, S Kargar, H Jalili, A Babaei… - Biocatalysis and …, 2024 - Elsevier
Lovastatin is a blood cholesterol reduction medicine and can be produced as a fungal
secondary metabolite. Although the industrial production of lovastatin is generally achieved …

Lovastatin production by Aspergillus terreus in membrane gradostat bioreactor with two-stage feeding strategy

S Kargar, S Mohseny Takloo, H Jalili… - Preparative …, 2023 - Taylor & Francis
Lovastatin is a blood cholesterol-lowering agent and is produced as a secondary metabolite
by Aspergillus terreus. Microbial production of this drug is carried out in solid-state or …

Impact of elicitors (alginate, Bacillus cereus, and cholesterol) on the production of secondary metabolite (lovastatin,(+)-geodin, and sulochrin) by Aspergillus terreus …

NSM Zaini, H Hasan, A Abbas, A Montoya… - Biocatalysis and …, 2024 - Elsevier
This study explored the impact of elicitors (sodium alginate (SA), microbial contamination in
the form of Bacillus cereus (MC), and cholesterol) on the synthesis of lovastatin,(+)-geodin …