Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis—a meta-analysis of comparative and non-comparative clinical trials

J Zwang, PL Olliaro - PLoS neglected tropical diseases, 2014 - journals.plos.org
Background Extensive use of praziquantel for treatment and control of schistosomiasis
requires a comprehensive understanding of efficacy and safety of various doses for different …

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

R Liu, HF Dong, Y Guo, QP Zhao, MS Jiang - Parasites & vectors, 2011 - Springer
Background Praziquantel has been used as first-line drug for chemotherapy of
schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also …

Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review

CH King, SK Olbrych, M Soon, ME Singer… - PLoS neglected …, 2011 - journals.plos.org
Background Controversy persists about the optimal approach to drug-based control of
schistosomiasis in high-risk communities. In a systematic review of published studies, we …

Efficacy and safety of praziquantel 40 mg/kg in preschool-aged and school-aged children: a meta-analysis

J Zwang, P Olliaro - Parasites & vectors, 2017 - Springer
Background Children carry most of the schistosomiasis burden. While school-aged children
are the principal target group of preventive chemotherapy with praziquantel, limited …

Application of nanotechnologies for improved immune response against infectious diseases in the developing world

M Look, A Bandyopadhyay, JS Blum… - Advanced drug delivery …, 2010 - Elsevier
There is an urgent need for new strategies to combat infectious diseases in developing
countries. Many pathogens have evolved to elude immunity and this has limited the utility of …

History of schistosomiasis epidemiology, current status, and challenges in China: on the road to schistosomiasis elimination

LG Song, XY Wu, M Sacko, ZD Wu - Parasitology research, 2016 - Springer
Schistosomiasis is a snail-borne disease caused by worms of the genus Schistosoma.
Worldwide, human schistosomiasis remains a serious public health problem, threatening∼ …

Efficacy of praziquantel treatment regimens in pre-school and school aged children infected with schistosomiasis in sub-Saharan Africa: a systematic review

M Kabuyaya, MJ Chimbari, S Mukaratirwa - Infectious diseases of poverty, 2018 - Springer
Background Schistosomiasis is a serious public health burden in sub-Saharan Africa.
Praziquantel is the only drug recommended by the World Health Organization to treat both …

Distribution of schistosomiasis and soil transmitted helminthiasis in Zimbabwe: towards a national plan of action for control and elimination

N Midzi, T Mduluza, MJ Chimbari… - PLoS neglected …, 2014 - journals.plos.org
Background Schistosomiasis and STH are among the list of neglected tropical diseases
considered for control by the WHO. Although both diseases are endemic in Zimbabwe, no …

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

M Fukushige, M Chase-Topping… - PLoS Neglected …, 2021 - journals.plos.org
Background The antihelminthic drug praziquantel has been used as the drug of choice for
treating schistosome infection for more than 40 years. Although some epidemiological …

Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children

GL Kay, A Millard, MJ Sergeant, N Midzi… - PLoS neglected …, 2015 - journals.plos.org
Background Several infectious diseases and therapeutic interventions cause gut microbe
dysbiosis and associated pathology. We characterised the gut microbiome of children …