HMGB1 as a therapeutic target in disease
J Xue, JS Suarez, M Minaai, S Li… - Journal of cellular …, 2021 - Wiley Online Library
High‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein
involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 …
involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 …
Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: a review
J Sadri Nahand, M Moghoofei… - … journal of cancer, 2020 - Wiley Online Library
Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most
important risk factor for the development of CC is cervical infection with human papilloma …
important risk factor for the development of CC is cervical infection with human papilloma …
SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells
Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …
MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
AM Strubberg, BB Madison - Disease models & …, 2017 - journals.biologists.com
MicroRNAs (miRNAs) are small single-stranded RNAs that repress mRNA translation and
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …
Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy
J Xue, S Patergnani, C Giorgi… - Proceedings of the …, 2020 - National Acad Sciences
Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading
to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as …
to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as …
[HTML][HTML] Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis
MA Proença, JM Biselli, M Succi… - World journal of …, 2018 - ncbi.nlm.nih.gov
AIM To examine the effect of Fusobacterium nucleatum (F. nucleatum) on the
microenvironment of colonic neoplasms and the expression of inflammatory mediators and …
microenvironment of colonic neoplasms and the expression of inflammatory mediators and …
MiR-34a promotes apoptosis and inhibits autophagy by targeting HMGB1 in acute myeloid leukemia cells
L Liu, W Ren, K Chen - Cellular Physiology and Biochemistry, 2017 - karger.com
Background: MiR-34a is identified as a tumor suppressor gene and involved in acute
myeloid leukemia (AML) development. However, the regulatory mechanism of miR-34a in …
myeloid leukemia (AML) development. However, the regulatory mechanism of miR-34a in …
MicroRNAs in gynecological cancers: Small molecules with big implications
Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy
of available therapeutic options. Thus, there remains an urgent and unmet need for …
of available therapeutic options. Thus, there remains an urgent and unmet need for …
Cervical cancer development, chemoresistance, and therapy: a snapshot of involvement of microRNA
T Mitra, S Elangovan - Molecular and Cellular Biochemistry, 2021 - Springer
Cervical cancer (CC) is one of the leading causes of death in women due to cancer and a
major concern in the developing world. Persistent human papilloma virus (HPV) infection is …
major concern in the developing world. Persistent human papilloma virus (HPV) infection is …
HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer
KJ Cheng, MA Alshawsh, EH Mejia Mohamed… - Cellular Oncology, 2020 - Springer
Background In recent years, the high mobility group box-1 (HMGB1) protein, a damage-
associated molecular pattern (DAMP) molecule, has been found to play multifunctional roles …
associated molecular pattern (DAMP) molecule, has been found to play multifunctional roles …