Zebrafish as tools for drug discovery
CA MacRae, RT Peterson - Nature reviews Drug discovery, 2015 - nature.com
The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …
contributed to several examples of successful phenotype-based drug discovery. For the …
Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …
emergence of systems approaches in biology promises new therapies, faster and cheaper …
New strategies for fluorescent probe design in medical diagnostic imaging
H Kobayashi, M Ogawa, R Alford, PL Choyke… - Chemical …, 2010 - ACS Publications
In vivo medical imaging has made great progress due to advances in the engineering of
imaging devices and developments in the chemistry of imaging probes. Several modalities …
imaging devices and developments in the chemistry of imaging probes. Several modalities …
Feeding behaviour and digestive physiology in larval fish: current knowledge, and gaps and bottlenecks in research
I Rønnestad, M Yufera, B Ueberschär… - Reviews in …, 2013 - Wiley Online Library
Food uptake follows rules defined by feeding behaviour that determines the kind and
quantity of food ingested by fish larvae as well as how live prey and food particles are …
quantity of food ingested by fish larvae as well as how live prey and food particles are …
Zebrafish: an important tool for liver disease research
W Goessling, KC Sadler - Gastroenterology, 2015 - Elsevier
As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …
[HTML][HTML] In vivo drug discovery in the zebrafish
LI Zon, RT Peterson - Nature reviews Drug discovery, 2005 - nature.com
The zebrafish has become a widely used model organism because of its fecundity, its
morphological and physiological similarity to mammals, the existence of many genomic tools …
morphological and physiological similarity to mammals, the existence of many genomic tools …
Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota
Animals have developed the means for supporting complex and dynamic consortia of
microorganisms during their life cycle. A transcendent view of vertebrate biology therefore …
microorganisms during their life cycle. A transcendent view of vertebrate biology therefore …
[HTML][HTML] The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
Z Li, LB Agellon, TM Allen, M Umeda, L Jewell… - Cell metabolism, 2006 - cell.com
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in
mammalian membranes. In liver, PC is synthesized via the choline pathway or by …
mammalian membranes. In liver, PC is synthesized via the choline pathway or by …
[HTML][HTML] Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation
JM Bates, E Mittge, J Kuhlman, KN Baden… - Developmental …, 2006 - Elsevier
All animals exist in intimate associations with microorganisms that play important roles in the
hosts' normal development and tissue physiology. In vertebrates, the most populous and …
hosts' normal development and tissue physiology. In vertebrates, the most populous and …