Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …

Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal
human somatic cells but is reactivated during tumor progression. We report the cloning of a …

The maintenance of chromosome termini, or telomeres, requires the action of the enzyme
telomerase, as conventional DNA poly-merases cannot fully replicate the ends of linear …

Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the
ends of eukaryotic chromosomes, called telomeres. In most human somatic cells …

Normal somatic cells have a finite life span [1] and lose telomeric DNA, present at the ends
of chromosomes, each time they divide as a function of age in vivo or in culture [2–4]. In …

Telomerase activation is thought to be a critical step in cellular immortalization and
carcinogenesis. Of the three major subunits comprising human telomerase, human …

Telomerase is a ribonucleoprotein enzyme that maintains telomere length by adding
telomeric sequence repeats onto chromosome ends. The essential RNA component of …

The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …