Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …

Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues.
By capturing, processing and presenting antigens to T cells, dendritic cells are essential for …

Single-nucleotide polymorphisms (SNPs) are the most frequent type of variation in the
human genome, and they provide powerful tools for a variety of medical genetic studies. In a …

An exceptional muscle development commonly referred to as 'double-muscled'(Fig. 1) has
been seen in several cattle breeds and has attracted considerable attention from beef …

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4+ T
lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 …

Induction of testis development in mammals requires the presence of the Y-chromosome
gene SPY. This gene must exert its effect by interacting with other genes in the sex …

The highly conserved and ubiquitously expressed 14‐3‐3 proteins regulate differentiation,
cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in …

Using the technique of differential cDNA library screening, a cDNA clone was isolated from
an estrogen receptor (ER)-positive breast carcinoma cell line (MCF7) cDNA library based …

THE great increase in successful linkage studies in a number of higher eukaryotes during
recent years has essentially resulted from major improvements in reference genetic linkage …