A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease
X Wu, X Zheng, H Tang, L Zhao, C He, Y Zou, X Song… - Medicine, 2022 - journals.lww.com
Background: Alzheimer disease (AD) is a degenerative brain disease, which may lead to
severe memory loss and other cognitive disorders. However, few effective drugs are …
severe memory loss and other cognitive disorders. However, few effective drugs are …
m5C RNA Methylation Primarily Affects the ErbB and PI3K–Akt Signaling Pathways in Gastrointestinal Cancer
5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and
RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on …
RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on …
Machine learning for discovery of GSK3β inhibitors
Alzheimer's disease (AD) is the most common cause of dementia, affecting approximately 35
million people worldwide. The current treatment options for people with AD consist of drugs …
million people worldwide. The current treatment options for people with AD consist of drugs …
Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors
JS Saleh, SR Abd El Hadi, HS Ibrahim, EZ Elrazaz… - BMC chemistry, 2023 - Springer
New thienopyrimidine derivatives were designed and synthesized as GSK-3β inhibitors
based on the structure of active binding site of GSK-3β enzyme. In this study, compounds 6b …
based on the structure of active binding site of GSK-3β enzyme. In this study, compounds 6b …
Transcriptional Regulation Analysis Provides Insight into the Function of GSK3β Gene in Diannan Small-Ear Pig Spermatogenesis
X Zhang, G Zhao, F Yang, C Li, W Lin, H Dai, L Zhai… - Genes, 2024 - mdpi.com
Glycogen synthase kinase-3β (GSK3β) not only plays a crucial role in regulating sperm
maturation but also is pivotal in orchestrating the acrosome reaction. Here, we integrated …
maturation but also is pivotal in orchestrating the acrosome reaction. Here, we integrated …
[PDF][PDF] In silico investigation of wound healing potential of some compounds in tubers of Asphodelus species with GSK3-β protein
H Aksoy, T Şekerler, NM Mert - Journal of research in pharmacy …, 2021 - researchgate.net
Wound healing is a process that involves biochemical processes such as inflammation and
cell proliferation and is controlled by many proteins. It is known that one of the most effective …
cell proliferation and is controlled by many proteins. It is known that one of the most effective …
温肾健脾方对脾肾阳虚证腹泻型肠易激综合征大鼠模型肠组织蛋白组学的影响.
长着, 李依洁, 魏玮, 刘瑜, 符思… - Chinese Journal of …, 2021 - search.ebscohost.com
目的探索温肾健脾方对脾肾阳虚证腹泻型肠易激综合征(IBS D) 大鼠肠组织蛋白组学的影响.
方法50 只雄性SD 大鼠随机分为健康对照组(n 组), 模型组(M 组), 温肾健脾方中剂量组(ZZ 组) …
方法50 只雄性SD 大鼠随机分为健康对照组(n 组), 模型组(M 组), 温肾健脾方中剂量组(ZZ 组) …
[PDF][PDF] Assessment of the size of Sella Turcica among nepalese Population by Computed Tomography
G Makaju, BR Joshi, RB Chand - Nepal J Radiol, 2019 - academia.edu
Introduction: The deformity of the sella turcica is often a major clue that an abnormality exists
within the cranium, hence a familiarity with the sella turcica anatomy and radiological …
within the cranium, hence a familiarity with the sella turcica anatomy and radiological …
Exploring PI3K Pathway Inhibitors for Acute Myeloid Leukemia: A Drug-Repurposing Approach
C Ergun, BZ Kiremitci, G Arslantaş, B Bozkurt… - Experimed, 2023 - dergipark.org.tr
Objective: Acute myeloid leukemia (AML) is a malignant disease characterized by the
uncontrolled growth, differentiation, and proliferation of immature hematopoietic cells …
uncontrolled growth, differentiation, and proliferation of immature hematopoietic cells …
Network pharmacology and metabolomics-based detection of the potential pharmacological effects of the active components in Chrysanthemum morifolium'Chuju'.
W Zhao, Q Ge, Z Ding, L Pan, Z Gu… - Journal of Chinese …, 2022 - search.ebscohost.com
Chrysanthemum morifolium‗ Chuju 'is a famous medicinal species in traditional Chinese
medicine.‗ Chuju 'contains various active ingredients that can be used to treat multiple …
medicine.‗ Chuju 'contains various active ingredients that can be used to treat multiple …