Targeting DNA damage response pathways in cancer
FJ Groelly, M Fawkes, RA Dagg, AN Blackford… - Nature Reviews …, 2023 - nature.com
Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …
Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor–resistant cancer
N Gupta, TT Huang, S Horibata, JM Lee - Pharmacological research, 2022 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) have become a
mainstay of therapy in ovarian cancer and other malignancies, including BRCA-mutant …
mainstay of therapy in ovarian cancer and other malignancies, including BRCA-mutant …
[HTML][HTML] ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
The ATR kinase safeguards genomic integrity during S phase, but how ATR protects DNA
replication forks remains incompletely understood. Here, we combine four distinct assays to …
replication forks remains incompletely understood. Here, we combine four distinct assays to …
Targeting the DNA damage response for cancer therapy by inhibiting the kinase Wee1
Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …
Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
N Böhly, AK Schmidt, X Zhang, BO Slusarenko… - Cell Reports, 2022 - cell.com
Chromosomal instability (CIN) is a hallmark of cancer and comprises structural CIN (S-CIN)
and numerical or whole chromosomal CIN (W-CIN). Recent work indicated that replication …
and numerical or whole chromosomal CIN (W-CIN). Recent work indicated that replication …
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells
F Jiang, L Wang, Y Dong, W Nie… - Proceedings of the …, 2023 - National Acad Sciences
Genetic alterations are often acquired during prolonged propagation of pluripotent stem
cells (PSCs). This ruins the stem cell quality and hampers their full applications …
cells (PSCs). This ruins the stem cell quality and hampers their full applications …
AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
PARP inhibitor (PARPi)–resistant BRCA-mutant (BRCAm) high-grade serous ovarian cancer
(HGSOC) represents a new clinical challenge with unmet therapeutic needs. Here, we …
(HGSOC) represents a new clinical challenge with unmet therapeutic needs. Here, we …
Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation
O Brison, S Gnan, D Azar, S Koundrioukoff… - Nature Structural & …, 2023 - nature.com
Genome integrity requires replication to be completed before chromosome segregation. The
DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which …
DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which …
Targeting the DNA damage response machinery for lung cancer treatment
KN Venugopala - Pharmaceuticals, 2022 - mdpi.com
Lung cancer is considered the most commonly diagnosed cancer and one of the leading
causes of death globally. Despite the responses from small-cell lung cancer (SCLC) and …
causes of death globally. Despite the responses from small-cell lung cancer (SCLC) and …