Nitroprusside─ Expanding the Potential Use of an Old Drug Using Nanoparticles

PM da Silva Filho, IA Paz, NRF Nascimento… - Molecular …, 2022 - ACS Publications
For more than 70 years, sodium nitroprusside (SNP) has been used to treat severe
hypertension in hospital emergency settings. During this time, a few other clinical uses have …

[HTML][HTML] Erectile dysfunction: pharmacological pathways with understudied potentials

DR Adam, MM Alem - Biomedicines, 2022 - mdpi.com
Erectile dysfunction (ED) is a public health concern worldwide. In the past, it was perceived
as a phenomenon attributed to age advancement. However, more individuals are affected …

The effect of low-intensity shock wave therapy on moderate erectile dysfunction: a double-blind, randomized, sham-controlled clinical trial

D Kalyvianakis, I Mykoniatis, N Pyrgidis… - Journal of …, 2022 - journals.lww.com
Purpose: We conducted the first double-blind, randomized, sham-controlled trial evaluating
the efficacy and safety of low-intensity shock wave therapy (LiST) exclusively in patients with …

Safety profile and signal detection of phosphodiesterase type 5 inhibitors for erectile dysfunction: a Food and Drug Administration Adverse Event Reporting System …

YE Shin, S Rojanasarot, AL Hincapie, JJ Guo - Sexual Medicine, 2023 - academic.oup.com
Background Phosphodiesterase type 5 inhibitors (PDE5Is) are generally well tolerated but
have been associated with uncommon and significant adverse events (AEs). Aim This study …

Synchronous surgical management of erectile dysfunction and stress urinary incontinence: A systematic review and meta-analysis of reoperation rates

N Pyrgidis, DW Barham, M Hammad… - Sexual medicine …, 2022 - academic.oup.com
Introduction The efficacy, safety, and postoperative outcomes of synchronous surgery for
concomitant erectile dysfunction (ED) and stress urinary incontinence (SUI) remain unclear …

[HTML][HTML] Canthin-6-Ones: Potential drugs for chronic inflammatory diseases by targeting multiple inflammatory mediators

Z Zhang, A Wang, Y Wang, W Sun, X Zhou, Q Xu… - Molecules, 2023 - mdpi.com
Chronic inflammatory disease (CID) is a category of medical conditions that causes
recurrent inflammatory attacks in multiple tissues. The occurrence of CID is related to …

The effect of combination treatment with low-intensity shockwave therapy and Tadalafil on mild and mild-to-moderate erectile dysfunction: a double-blind, randomized …

I Mykoniatis, N Pyrgidis, F Zilotis… - The journal of sexual …, 2022 - academic.oup.com
Background Combination of different first-line treatments for erectile dysfunction (ED) has
emerged as a promising therapeutic approach. Aim To conduct the first double-blind …

Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism

C Wang, H Zhang, F Wang, J Guo, J Yuan, G Hou… - The Aging …, 2024 - Taylor & Francis
Purpose Although several reviews have evaluated the use of PDE5 inhibitors (PDE5i) for
treating erectile dysfunction (ED), their specific use in middle-aged and old patients has not …

Application of terahertz Time-Domain spectroscopy and chemometrics-based whale optimization algorithm in PDE5 inhibitor detection

A Zhang, G Qin, J Wang, N Li, S Wu - Spectrochimica Acta Part A …, 2024 - Elsevier
Combating the illicit use of PDE5 inhibitor drugs is a focal point in forensic science research.
In order to achieve rapid identification of such drugs, this study applies terahertz time …

Phosphodiesterase‐5 Inhibitory Activity of Canthin‐6‐One Alkaloids and the Roots of Eurycoma longifolia and Eurycoma harmandiana

R Choonong, J Chaingam, R Chantakul… - Chemistry & …, 2022 - Wiley Online Library
Eurycoma longifolia (EL) and Eurycoma harmandiana (EH) are natural medicinal plants
belonging to the Simaroubaceae family, and are well‐known for their ability to enhance …