DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …

The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all
parts of the world, and melanoma is a leading cause of cancer death. As even relatively …

Purpose poly (ADP ribose) polymerase inhibition has been shown to potentiate the
cytotoxicity of DNA damaging agents. A phase I study of rucaparib and temozolomide …

Immunotherapy prolongs survival in only a subset of melanoma patients, highlighting the
need to better understand the driver tumor microenvironment. We conducted bioinformatic …

We characterized the oxidative stress (OS) status by the levels of reduced/oxidized
glutathione (GSH/GSSG), malondialdehyde (MDA) and the mutagenic base 8-oxo-7′ 8 …

Purpose: For primary melanomas, tumor thickness, mitotic rate, and ulceration are well-laid
cornerstones of prognostication. However, a molecular exposition of melanoma …

The American Joint Committee on Cancer staging system for cutaneous melanoma is based
on primary tumor thickness and the presence of ulceration, mitoses, lymph node spread, and …

WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint
and to be involved in tumour progression in different malignant tumours. Here we analysed …

The immune response to melanoma improves the survival in untreated patients and predicts
the response to immune checkpoint blockade. Here, we report genetic and environmental …

Targeted therapies against components of the mitogen-activated protein kinase (MAPK)
pathway and immunotherapies, which block immune checkpoints, have shown important …