Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Proteomics researchers today face an interesting challenge: how to choose among the
dozens of data processing and analysis pipelines available for converting tandem mass …

Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …

Sperm motility is crucial to reproductive success in sexually reproducing organisms.
Impaired sperm movement causes male infertility, which is increasing globally. Sperm are …

The mammalian respiratory chain complexes I, III 2, and IV (CI, CIII 2, and CIV) are critical for
cellular bioenergetics and form a stable assembly, the respirasome (CI-CIII 2-CIV), that is …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

Plants are foundational for global ecological and economic systems, but most plant proteins
remain uncharacterized. Protein interaction networks often suggest protein functions and …

Protein–protein interactions are fundamental to various aspects of cell biology with many
protein complexes participating in numerous fundamental biological processes such as …

The signal peptidase complex (SPC) is an essential membrane complex in the endoplasmic
reticulum (ER), where it removes signal peptides (SPs) from a large variety of secretory pre …

INTRODUCTION Genome-sequencing efforts over the past decade have profiled the genetic
landscape of thousands of tumors and solidified the concept of cancer as a highly …