Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

Neuroactive compounds are synthesized by certain plants and microorganisms by
undertaking different tasks, especially as a stress response. Most common neuroactive …

Objectives The therapeutic use of nutrient-based 'nutraceuticals' and plant-based
'phytoceuticals' for the treatment of mental disorders is common; however, despite recent …

L-5-hydroxytryptophan (5-HTP) is both a drug and a natural component of some dietary
supplements. 5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is …

Depression is a highly common mental disorder, which is often multifactorial with sex,
genetic, environmental, and/or psychological causes. Recent advancements in biomedical …

Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize
previous findings that serotonin regulates executive function, sensory gating, and social …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Sleep restriction and circadian clock disruption are associated with metabolic disorders such
as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human …

Serotonergic hallucinogens such as lysergic acid diethylamide (LSD) induce head twitches
in rodents via 5-HT 2A receptor activation. The goal of the present investigation was to …

Serotonin and vitamin D have been proposed to play a role in autism; however, no causal
mechanism has been established. Here, we present evidence that vitamin D hormone …