[HTML][HTML] Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems

HM Diab, IA Abdelhamid, ME Salem, I Ragab… - Results in …, 2024 - Elsevier
Synthesis of analogs of known active compounds is the most often employed strategy for
producing important compounds. The Hantzsch reaction was employed to create new star …

Novel α-Cyano-Indolyl Chalcones as Anti-Cancer Candidates, Induce G1/S Cell Cycle Arrest and Sequentially Activate Caspases-7, 8, and 9 in Breast Carcinoma

AA Kashmiry, NS Ibrahim, MF Mohamed… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Six substituted α-cyano-indolylchalcones have been prepared and their structures were
verified by various spectral analysis tools. Compared with the standard drug 5-Fluorouracil) …

Synthesis, antimicrobial, DNA binding, and computational studies of some bis-and poly (4-methyl-2H-chromen-2-one) derivatives

IMZ Fares, MA Ragheb, IA Abdelhamid… - Journal of Molecular …, 2025 - Elsevier
The research focused on studying how 7-hydroxy-4-methyl-2H-chromen-2-one can be used
as a building material for new bis-and poly (coumarins) through alkylation with related bis …

New Halogenated Chalcones as Potential Anti-Inflammatory Agents: A Comprehensive In-Silico, In-Vitro, and In-Vivo Study with ADME Profiling

R Iqtadar, A Naz, SAA Shah, S Ali… - Journal of Molecular …, 2024 - Elsevier
This study explored the anti-inflammatory potential of halogenated chalcone derivatives
using in-silico, in-vitro and in-vivo models. The synthesized compounds were assessed for …