Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Exposure to traumatic or infectious insults results in a rapid activation of the complement
cascade as major fluid defense system of innate immunity. The complement system acts as …

Abstract Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling,
which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various …

Abstract Introduction Dental pulp fibroblasts (DPFs) are the most abundant cell type in the
dental pulp. They play pivotal roles; however, they are often mistaken to be involved only in …

The exact pathophysiology of severe COVID-19 is not entirely elucidated, but it has been
established that hyperinflammatory responses and cytokine storms play important roles. The …

Complement not only plays a key role in host microbial defense but also modulates the
adaptive immune response through modification of T-and B-cell reactivity. Moreover, a …

Blast exposure, commonly experienced by military personnel, can cause devastating life-
threatening polysystem trauma. Despite considerable research efforts, the impact of the …

Complementopathy, endotheliopathy, and coagulopathy following a traumatic injury are key
pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) …

The incidence of musculoskeletal diseases is steadily increasing with aging of the
population. In the past years, extracellular vesicles (EVs) have gained attention in …

Background and Purpose Traumatic haemorrhage (TH) is the leading cause of potentially
preventable deaths that occur during the prehospital phase of care. No effective …