Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …

Like all other mammals, humans harbour an astonishing number of endogenous
retroviruses (ERVs), as well as other retroelements, embedded in their genome. These …

Tumour cells release an abundance of microvesicles containing a selected set of proteins
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …

Retroviruses that have the ability to infect germ line cells can become an integral and
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …

Retroelements constitute approximately 45% of the human genome. Long interspersed
nuclear element (LINE) autonomous retrotransposons are predominantly represented by …

Our defenses against infection rely on the ability of the immune system to distinguish
invading pathogens from self. This task is exceptionally challenging, if not seemingly …

While specific genes are hypermethylated in the genome of cancer cells, overall
methylcytosine content is often decreased as a consequence of hypomethylation affecting …

The published human genome sequence contains many thousands of endogenous
retroviruses (HERVs) but all are defective, containing nonsense mutations or major …

In diseases where epigenetic mechanisms are changed, such as cancer, many genes show
altered gene expression and inhibited genes become activated. Human endogenous …

Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …