Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being
S Wolf, J Becker, Y Tsuge, H Kawaguchi… - Essays in …, 2021 - portlandpress.com
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial
biotechnology and has become famous for its power to synthetise amino acids and a range …
biotechnology and has become famous for its power to synthetise amino acids and a range …
Comprehensive screening of industrially relevant components at genome scale using a high-quality gene overexpression collection of Corynebacterium glutamicum
J Liu, X Zhao, H Cheng, Y Guo, X Ni, L Wang… - Trends in …, 2024 - cell.com
Abstract Development of efficient microbial strains for biomanufacturing requires deep
understanding of the biology and functional components responsible for the synthesis …
understanding of the biology and functional components responsible for the synthesis …
Development of a workflow for the selection, identification and optimization of lactic acid bacteria with high γ-aminobutyric acid production
A Rehman, G Di Benedetto, JK Bird, V Dabene… - Scientific Reports, 2023 - nature.com
Lactic acid bacteria produce γ-aminobutyric acid (GABA) as an acid stress response. GABA
is a neurotransmitter that may improve sleep and resilience to mental stress. This study …
is a neurotransmitter that may improve sleep and resilience to mental stress. This study …
Adaptive laboratory evolution accelerated glutarate production by Corynebacterium glutamicum
Background The demand for biobased polymers is increasing steadily worldwide. Microbial
hosts for production of their monomeric precursors such as glutarate are developed. To meet …
hosts for production of their monomeric precursors such as glutarate are developed. To meet …
Production of γ-Aminobutyrate (GABA) in Recombinant Corynebacterium glutamicum by Expression of Glutamate Decarboxylase Active at Neutral pH
J Son, KA Baritugo, YJ Sohn, KH Kang, HT Kim… - ACS …, 2022 - ACS Publications
γ-Aminobutyrate (GABA) is an important chemical by itself and can be further used for the
production of monomer used for the synthesis of biodegradable polyamides. Until now …
production of monomer used for the synthesis of biodegradable polyamides. Until now …
Enhanced accumulation of γ-aminobutyric acid by deletion of aminotransferase genes involved in γ-aminobutyric acid catabolism in engineered Halomonas elongata
Z Zou, P Kaothien-Nakayama… - Applied and …, 2024 - journals.asm.org
Halomonas elongata OUT30018 is a moderately halophilic bacterium that synthesizes and
accumulates ectoine as an osmolyte by activities of the enzymes encoded by the high …
accumulates ectoine as an osmolyte by activities of the enzymes encoded by the high …
Heat stress and excessive maturity of fruiting bodies suppress GABA accumulation by modulating GABA metabolism in Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm
Q Wen, H Zhao, Y Shao, J Li, Y Hu, Y Qi, F Wang… - Food Research …, 2023 - Elsevier
GABA is a health-promoting bioactive substance. Here, the GABA biosynthetic pathways
were investigated, and then the dynamic quantitative changes in GABA and the expression …
were investigated, and then the dynamic quantitative changes in GABA and the expression …
Fermentative Production of l-2-Hydroxyglutarate by Engineered Corynebacterium glutamicum via Pathway Extension of l-Lysine Biosynthesis
C Prell, A Burgardt, F Meyer… - Frontiers in Bioengineering …, 2021 - frontiersin.org
l-2-hydroxyglutarate (l-2HG) is a trifunctional building block and highly attractive for the
chemical and pharmaceutical industries. The natural l-lysine biosynthesis pathway of the …
chemical and pharmaceutical industries. The natural l-lysine biosynthesis pathway of the …
Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ‐aminobutyrate and 5‐aminovalerate and their role in activating sensor kinases
JP Cerna‐Vargas, T Krell - MicrobiologyOpen, 2024 - Wiley Online Library
The standard method of receptor activation involves the binding of signals or signal‐loaded
solute binding proteins (SBPs) to sensor domains. Many sensor histidine kinases (SHKs) …
solute binding proteins (SBPs) to sensor domains. Many sensor histidine kinases (SHKs) …
[HTML][HTML] Improve gamma-aminobutyric acid production in Corynebacterium glutamicum by optimizing the metabolic flux
C Yao, Y Liu, X Hu, X Wang - Systems Microbiology and Biomanufacturing, 2022 - Springer
Gamma-aminobutyric acid is an important nonprotein amino acid and has been extensively
applied in pharmaceuticals, livestock, food additives, and so on. It is important to develop …
applied in pharmaceuticals, livestock, food additives, and so on. It is important to develop …