Commercial nerve guidance conduits (NGCs) for repair of peripheral nerve discontinuities
are of little use in gaps larger than 30 mm, and for smaller gaps they often fail to compete …

The technologies related to ex vivo models and lab-on-a-chip devices for studying the
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …

We hypothesize that innate immune signals from infectious organisms and/or injured tissues
may activate peripheral neuronal pain signals. In this study, we demonstrated that TLRs 3, 7 …

Abstract Development of “organ-on-a-chip” systems for neuroscience applications are
lagging due in part to the structural complexity of the nervous system and limited access of …

Neurotrophic factor delivery via biodegradable nerve guidance conduits may serve as a
promising treatment for the repair of large peripheral nerve defects. However, a platform for …

Fast axonal conduction depends on myelin, which is formed by Schwann cells in the PNS.
We found that the transcription factor Yin Yang 1 (YY1) is crucial for peripheral myelination …

Abstract Interleukin-4 (IL-4) has garnered interest as a cytokine that mediates regeneration
across multiple tissues including peripheral nerve. Within nerve, we previously showed …

Nerve guidance conduits (NGCs) are sub-optimal for long-distance injuries with
inflammation and poor vascularization related to poor axonal repair. This study used a multi …

Myelinating Schwann cell (SC)–dorsal root ganglion (DRG) neuron cocultures are an
important technique for understanding cell–cell signalling and interactions during peripheral …

The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe
neurological disorders affecting the peripheral and central nervous systems (PNS and CNS …