Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …

Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

Sensory neurons innervating the skin encode the familiar sensations of temperature, touch
and pain. An explosion of progress has revealed unanticipated cellular and molecular …

Primary cilia are solitary, tiny organelles that project from the membrane of most mammalian
cells. Housing components of the cell division apparatus between cell divisions, they also …

Ion channels of the transient receptor potential (TRP) superfamily are involved in a wide
variety of neural signalling processes, most prominently in sensory receptor cells. They are …

Mechanosensitive ion channels are gated directly by physical stimuli and transduce these
stimuli into electrical signals. Several criteria must apply for a channel to be considered …

Cilia are microtubule-based organelles that project like antennae from the surface of most
cells in the body. Motile cilia move fluid past cells, for example mucus in the airway. Non …

The sense of touch detects forces that bombard the body's surface. In metazoans, an
assortment of morphologically and functionally distinct mechanosensory cell types are tuned …

Mechanical stimuli generated by head movements and changes in sound pressure are
detected by hair cells with amazing speed and sensitivity. The mechanosensitive organelle …