The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic
reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …

During cotranslational translocation, the signal peptide of a nascent chain binds Sec61
translocon to initiate protein transport through the endoplasmic reticulum (ER) membrane …

The heterotrimeric Sec61 complex is a major site for the biogenesis of transmembrane
proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic …

Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy,
but attempts to target essential protein biogenesis factors have been hampered by …

The Sec61 complex is the major protein translocation channel of the endoplasmic reticulum
(ER), where it plays a central role in the biogenesis of membrane and secretory proteins …

Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …

Protein translocation across the endoplasmic reticulum (ER) membrane is an essential step
during protein entry into the secretory pathway. The conserved Sec61 protein‐conducting …